Kliniska prövningar på Hemodilution - Kliniska - ICH GCP

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An experimental study in the rabbit. This page in English. Författare: Lieselotte Frost- The effect of hemodilution on free flap survival: A systematic review of clinical and experimental studies. Forskningsöversiktsartikel (Review article) The aims of our study were to describe the hemodynamic effects of normovolemic hemodilution and to determine its effect on systolic and diastolic cardiac Villkor: Acute Normovolemic Hemodilution; Off-Pump Coronary Artery Bypass Effect of Aspirin, Hemodilution and Desmopressin on Platelet Dysfunction. The application of acute Normovolemic Hemodilution in cardiac surgery can Effect of Large Volume Acute Normovolemic Hemodilution on Perioperative Witb a volume expansion effect of about 50% an increase in intravascular volume of 750 ml (500 mi Haes and 250 mi tissue water) is expected immediately after Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet hemodilution. Hemodilution with dextran: Effects on blood flow and thrombus formation.

Hemodilution effect

Metoden används kliniskt 1) vid tillstånd med försämrad mikrocirkulation, 2) vid ersättning av förlorat blod vid operationer utan homolog blodtransfusion och 3) vid hjärt-lung-bypass och hypotermi. Hemodilution increased myocardial blood flow, and reducing the FI O 2 from 1.0 to 0.15 caused a further increase . The severe hemodilution thus did not exhaust the potential for coronary vasodilation. The extent of hemodilution and the effect on serologies and NAT is poorly understood and urgently needed as more ECDs are recruited. Aim To re-evaluate currently use hemodilution algorithm 48 hrs prior to consent/blood draw. Background and Purpose To evaluate the effects of hemodilution on cerebral hemodynamics and oxygen metabolism in the normal human brain, we measured regional cerebral blood flow, oxygen extraction fraction, oxygen metabolic rate, and regional cerebral blood volume in eight normal volunteers before and after hemodilution using positron emission tomography and oxygen-15–labeled gas inhalation Briden KL, Teltzer M, Weiss HR (1979) The effect of mild normovolemic hemodilution on regional flow, oxygenation an small vessel blood content in the rabbit heart subjected to acute coronary occlusion.

Additionally, the PFCOC performed differently in the two places, transporting and delivering more oxygen at sea level and becoming a more significant source of oxygen than at 2,600 m. Hemodilution, by decreasing viscosity, will increase flow rates and may decrease the time necessary to transfuse a unit of RBC. However, it is unknown if the effect of the decrease in viscosity would offset the time necessary to deliver the expanded volume of a diluted unit of RBCs.

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An experimental study in the rabbit. This page in English. Författare: Lieselotte Frost- The effect of hemodilution on free flap survival: A systematic review of clinical and experimental studies.

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This study evaluates the effect of blood volume and hematocrit changes on brain tissue during temporary global ischemia.

2526 Hemodilution elicits venomotor activity dominated by aortic chemoreceptors and results in increased venous return, which may also be a factor that influences cardiac output by lowering viscosity.
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Effect of albumin and mannitol on organ blood flow, oxygen delivery, water content, and renal function during hypothermic hemodilution cardiopulmonary bypass. Ann Thorac Surg 1982 ; 33: 250 – 257 . This was related to a marked blunting of the cardiac output response to hemodilution in the animals receiving the higher anesthetic dosage. CONCLUSIONS: Increased anesthetic depth with halothane or ketamine resulted in a decreased tolerance to acute anemia, as reflected by a significant increase in critical hemoglobin concentration.

Blood loss was the next most important resulting in an average 6% drop in factor levels during CPB, but the range was quite variable with some patients showing little change whereas others showed up to a 14% decrease in factor levels attributed to blood loss. Clinically, the most noticeable effect of hemodilution is a marked reduction in the perfusion pressure at initiation of CPB. Gordon et al. showed that when hemodilution is used to decrease the hematocrit and when the flow rate on CPB is held constant, the perfusion pressure decreases in direct proportion to the change in viscosity . The potential impact of hemodilution on blood transfusions It is well established that iatrogenic hemodilution may lead to increased blood transfusion due to dilutional coagulopathy and increased surgical bleeding. Effect of albumin and mannitol on organ blood flow, oxygen delivery, water content, and renal function during hypothermic hemodilution cardiopulmonary bypass. Ann Thorac Surg 1982 ; 33: 250 – 257 .
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The effect of hemodilution in NAION using hydroxyethyl starch infusion was investigated in a prospective randomized study in 1991. The initial results showed an improvement of visual acuity three months after isovolemic hemodilution in six of eleven patients in comparison to one of ten patients in the control group ( ) [ 20 ]. The effect of hemodilution during normothermic cardiac surgery on renal physiology and function: a review Although the definitions of renal dysfunction vary, loss of renal function is a common complication following cardiac surgery using cardiopulmonary bypass (CPB). 22 Pries AR Secomb TW Sperandio M Gaehtgens P . Blood flow resistance during hemodilution: effect of plasma composition.

Results: (a) In prior studies using native plasma for hemodilution R0 averaged 50 +/- 8% of R0.45, while in studies using artificial solutions R0 averaged 32 +/- 12% of R0.45. The larger reduction of flow resistance upon dilution with artificial media is independent of viscosity and oncotic pressure. Other design characteristics did not show strong significant effects. The mild hemodilution does not have a high negative impact on the oxygen-carrying capacity of blood, blood coagulation or in the heart, brain and kidneys, while allowing the collection of enough autologous blood; 3) When a large amount of blood needs to be collected, erythropoietin and iron are administered to promote the formation and maturation of erythrocytes in patients, preventing preoperative anemia. Iatrogenic hemodilution: a possible cause for avoidable blood transfusions?
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acute effect — Svenska översättning - TechDico

In view of a growing interest in the resuscitative use of hypertonic saline solutions, the authors have examined the cerebral effects of isovolemic hemodilution carried out over 1 hour (hematocrit decreased from 40% to 20%, stable arterial and right arterial pressures), using a hypertonic lactated Ringer's solution (HT-LR:Na + 252 mEq/liter, osmolality 480 mOsm/liter). The effect of hemodilution in NAION using hydroxyethyl starch infusion was investigated in a prospective randomized study in 1991. The initial results showed an improvement of visual acuity three months after isovolemic hemodilution in six of eleven patients in comparison to one of ten patients in the control group ( ) [ 20 ]. The effect of hemodilution during normothermic cardiac surgery on renal physiology and function: a review Although the definitions of renal dysfunction vary, loss of renal function is a common complication following cardiac surgery using cardiopulmonary bypass (CPB). 22 Pries AR Secomb TW Sperandio M Gaehtgens P . Blood flow resistance during hemodilution: effect of plasma composition.

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Transfusion. Akut normovolemisk hemodilution. Effects of standardized acute normovolemic hemodilution on intraoperative allogeneic blood transfusion in patients during hypervolemia, hemodilution, and hypertension therapy in patients with Response to "Letter to the Editor" by R. Dhar: Re: Effect of HHH-Therapy on hemodilution och hypotermi, men också av det kirurgiska traumat och pre- och perioperativ medicinering, exempelvis trombocythämmare och heparin (3-5). Although this might be an effect of colloid-induced coagulopathy, we found no dose-dependent effect of HES. The unactivated fibrinolysis indicates that Hemodilution with dextran: effects on blood flow and thrombus formation: an experimental study in the rabbit.

acute effect — Svenska översättning - TechDico

Although early animal studies indicated a potential benefit to hemodilution, strengthening the belief that hemodilution during cardiac surgery was without consequence, 13,14 most of these studies were limited in that they did not mimic CPB or reduce hematocrit below 30%. Abstract. Objective: Hemodilution has been associated with both hypocoagulability and hypercoagulability in studies based on thromboelastography (TEG). Severe hemodilution during cardiopulmonary bypass (CPB) is a risk factor for morbidity in cardiac surgery. This study investigated the effects of different degrees of hemodilution with CPB on post-CPB TEG parameters and coagulation-related outcomes.

Surg Forum 24: 201 – 203, 1973 Laks H, O'Connor NE, Pilon RN, et al: Acute normovolemic hemodilution: effects on hemodynamics, oxygen transport, and lung water in anesthetized man. In view of a growing interest in the resuscitative use of hypertonic saline solutions, the authors have examined the cerebral effects of isovolemic hemodilution carried out over 1 hour (hematocrit decreased from 40% to 20%, stable arterial and right arterial pressures), using a hypertonic lactated Ringer's solution (HT-LR:Na + 252 mEq/liter, osmolality 480 mOsm/liter). The effect of hemodilution in NAION using hydroxyethyl starch infusion was investigated in a prospective randomized study in 1991. The initial results showed an improvement of visual acuity three months after isovolemic hemodilution in six of eleven patients in comparison to one of ten patients in the control group ( ) [ 20 ]. The effect of hemodilution during normothermic cardiac surgery on renal physiology and function: a review Although the definitions of renal dysfunction vary, loss of renal function is a common complication following cardiac surgery using cardiopulmonary bypass (CPB). 22 Pries AR Secomb TW Sperandio M Gaehtgens P . Blood flow resistance during hemodilution: effect of plasma composition.